Examples describe potential review areas, not a fixed panel. Coverage and relevance are checked for each file.
NUTRIENT METABOLISM — Selected MTHFR, MTR and MTRR variants are studied in folate-related pathways; BCMO1/BCO1 in beta-carotene conversion; FADS1/FADS2 in fatty-acid profiles. Examples include MTHFR C677T, BCMO1 rs7501331, and the FADS-region rs174537. Findings are considered with diet and supplied labs. A common MTHFR variant does not diagnose deficiency or mandate methylated supplements.
FOOD & CAFFEINE — The LCT/MCM6 region, including rs4988235 in relevant populations, provides lactase-persistence information. CYP1A2 and ADORA2A are studied in caffeine metabolism and response. Ancestry, observed tolerance, serving size, intake, and sleep matter. These findings do not diagnose allergy or celiac disease or determine a universally reliable caffeine dose.
CARDIOMETABOLIC NUTRITION — Selected FADS1/FADS2 and appropriately scoped APOE-related information may add context to dietary-fat and lipid discussions alongside supplied lipid results. APOE inclusion requires prior discussion and consent because it can reveal information beyond nutrition. Genotype alone does not determine treatment.
APPETITE & WEIGHT — FTO (for example, rs9939609) and common MC4R-region variants are studied in population-level weight and appetite traits. Findings are interpreted with meal patterns, food environment, sleep, and activity. Associations do not diagnose an individual cause of obesity or identify a superior weight-loss diet. Common MC4R-region variants differ from rare pathogenic MC4R variants.
WOMEN’S HEALTH & HEALTHY AGING — Selected nutrient- and lipid-related findings may complement assessment of dietary adequacy and cardiometabolic nutrition. Protein, bone- and muscle-supportive eating, lifestyle, and clinical context remain central. Consumer DNA does not replace hormonal evaluation, determine menopause treatment, or predict lifespan.
METHYLATION & CYP CONTEXT — Common folate-pathway variants do not measure whole-body methylation or establish vitamin status. Supplied folate/B12 and homocysteine results may add clinical context. CYP enzymes process caffeine, some medications, and environmental compounds; a nutrition review does not measure toxic burden. Medication decisions require validated clinical pharmacogenetic testing and the prescribing clinician.
FDA pharmacogenetic associations.